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CAS NO. | 1383982-64-6 | |
Product Name | AZD3293 | |
Synonyms | LY 3314814 | |
Formula | C26H28N4O | |
Molecular Weight | 412.54 | |
Spec / Purity | 98%min | |
Supply Capacity | ||
Details | AZD3293 is an inhibitor of BACE1, the ß-secretase sheddase that cleaves the APP protein to release APP's C99 fragment. This fragment then becomes a substrate for subsequent ?-secretase cleavage and Aß peptide generation. The rationale is that inhibiting BACE1 will reduce amyloid-related toxicity in Alzheimer's disease. AZD3293 is one of several BACE1/2 inhibitors currently in development. Preclinical data have not been formally published. AZD3293 is administered in tablet form. |
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